The game follows the events of Pirates of the Caribbean: Dead Man's Chest.
Dead Man's Chest is a third-person action-adventure game, though the Gameboy Advance version is a 2D side-scroller. Minigames include Shoot the Monkey, Walk the Plank, and Boom Barge.
Jack Sparrow is the main playable character, though Will Turner and Elizabeth Swann are also playable in the DS version of the game. Lord Cutler Beckett, James Norrington, a Mortician, a voodoo doll, a pirate captain, and a Pelegostos warrior are also playable characters in the DS version of the game.
Dead Man's Chest follows the main events of the film, with some minor changes and additions. Players begin by helping Jack Sparrow escape from the Turkish Prison, and then go on to control Will, Elizabeth, and Jack in numerous other locations, including Tortuga, Isla de Pelegostos, and Port Royal. Enemies range from a wide variety, including British soldiers and Davy Jones' Crew. The game features numerous unlockables found both during the first playthough and after replaying levels, including storyline concept art and new characters.